Yukinori Arai Selected Research

conivaptan (Vaprisol)

1/2009	New topics in vasopressin receptors and approach to novel drugs: research and development of conivaptan hydrochloride (YM087), a drug for the treatment of hyponatremia.
1/2007	A novel vasopressin dual V1A/V2 receptor antagonist, conivaptan hydrochloride, improves hyponatremia in rats with syndrome of inappropriate secretion of antidiuretic hormone (SIADH).
1/2005	Intravenous administration of conivaptan hydrochloride improves cardiac hemodynamics in rats with myocardial infarction-induced congestive heart failure.
11/2002	Effect of conivaptan, a combined vasopressin V(1a) and V(2) receptor antagonist, on vasopressin-induced cardiac and haemodynamic changes in anaesthetised dogs.
8/2002	Effect of the vasopressin receptor antagonist conivaptan in rats with heart failure following myocardial infarction.

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Yukinori Arai Research Topics

Disease

4	Neoplasms (Cancer) 12/2021 - 03/2016
3	Hyponatremia 01/2009 - 01/2007
3	Heart Failure 01/2005 - 08/2002
2	Myocardial Infarction 01/2005 - 08/2002
1	Extranodal Extension 01/2020
1	Lung Neoplasms (Lung Cancer) 03/2016
1	Neutropenia 03/2016
1	Seizures (Absence Seizure) 01/2009
1	Inappropriate ADH Syndrome (SIADH) 01/2007
1	Coronary Occlusion 01/2005
1	Body Weight (Weight, Body) 01/2005

Drug/Important Bio-Agent (IBA)

5	conivaptan (Vaprisol)FDA Link 01/2009 - 08/2002
3	Interleukin-12 (IL 12)IBA 12/2021 - 01/2020
3	Interleukin-7 (Interleukin 7)IBA 12/2021 - 01/2020
3	SodiumIBA 01/2009 - 01/2007
3	Arginine Vasopressin (Argipressin)IBA 01/2009 - 01/2007
3	ElectrolytesIBA 01/2009 - 01/2007
3	Vasopressin Receptors (Arginine Vasopressin Receptor)IBA 01/2009 - 01/2005
3	Vasopressins (Vasopressin)IBA 01/2007 - 08/2002
2	Immune Checkpoint InhibitorsIBA 12/2021 - 01/2020
1	CTLA-4 AntigenIBA 01/2020
1	ASP9853IBA 03/2016
1	taxaneIBA 03/2016
1	Docetaxel (Taxotere)FDA Link 03/2016
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 03/2016
1	Furosemide (Lasix)FDA LinkGeneric 01/2007
1	salicylhydroxamic acid (SHAM)IBA 01/2005
1	Antidiuretic Hormone Receptor AntagonistsIBA 08/2002

Therapy/Procedure

3	Therapeutics 03/2016 - 04/2007
2	Intravenous Administration 01/2007 - 01/2005
1	Immunotherapy 01/2020
1	Oral Administration 08/2002